This medical condition has either been superseded or has become inactive
| Specific Conditions |
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| Level of Evidence | Insufficient data (Category 4a) |
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Intravenous immunoglobulin (IVIg) therapy may be indicated during pregnancy when there is a history of autoimmune congenital heart block in at least one previous pregnancy, and maternal SS-A and/or SS-B antibodies are present. Refer to the current product information sheet for further information. The aim should be to use the lowest dose possible that achieves the appropriate clinical outcome for each patient. |
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| Bibliography |
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| Buyon, JP, Kim, MY, Copel, JA, et al 2001, ‘Anti-Ro/SSA antibodies and congenital heart block: necessary but not sufficient’, Arthritis & Rheumatism, vol. 44, no. 8, pp. 1723–7. Kaaja, R & Julkunen, H 2003, ‘Prevention of recurrence of congenital heart block with intravenous immunoglobulin and corticosteroid therapy: comment on the editorial by Buyon et al’, Arthritis & Rheumatism, vol. 48, no. 1, pp. 280–1. Tran, HB, Cavill, D, Buyon, JP, et al 2004, ‘Intravenous immunoglobulin and placental transport of anti-Ro/La antibodies: comment on the letter by Kaaja and Julkunen’, Arthritis & Rheumatism, vol. 50, no. 1, pp. 337–8. Villain, E, Coastedoat-Chalumeau, N, Marijon, E, et al 2006, ‘Presentation and prognosis of complete atrioventricular block in childhood, according to maternal antibody status’, Journal of the American College of Cardiology, vol. 48, no. 8, pp. 1682–7. Wong, JP, Kwek, KY, Tan, JY, et al 2001, ‘Fetal congenital complete heart block: prophylaxis with intravenous gammaglobulin and treatment with dexamethasone’, Australia New Zealand Journal of Obstetrics and Gynaecology, vol. 41, no. 3, pp. 339–41. |