| Specific Conditions |
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| Level of Evidence | Insufficient data (Category 4a) |
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The use of Ig therapy is not supported for pure White Cell Aplasia because there is insufficient evidence of benefit and preferable alternative therapies are available for the treatment of this condition. There are no published randomised clinical trials in PWCA and the only published evidence remains single case presentations reporting vague associations of response to IVIg. Spontaneous resolution is expected following the removal of causal agents and treatment of underlying conditions with G-CSF (Granulocyte - Colony Stimulating Factor), Steroids or other immunosuppressant medications. |
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| Bibliography |
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| Anderson, D, Ali, K, Blanchette, V, et al 2007, ‘Guidelines on the use of intravenous immune globulin for hematologic conditions’, Transfusion Medicine Reviews, vol. 21, no. 2, suppl. 1, pp. S9–56. |