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Ig therapy is not supported for Diabetic amyotrophy (diabetic lumbosacral radiculoplexus neuropathy; DLRPN) as there is insufficient evidence to support the use of IVIg in this condition. There are no published controlled clinical trials, and one registered randomized clinical trial was terminated prematurely without publication. This approach is consistent with recommendations of the Canadian and North American IVIg criteria. A single prospective, randomized double-blind controlled trial of intravenous methylprednisolone, demonstrated significantly more improvement in neuropathic pain in the IVMP group, but no significant improvement in neuropathy impairment score (Class 1).
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